Publications

  1. Thapa, P., Li, M., Karki, R., Bio, M., Rajaputra, P., Nkepang, G., Woo, S., You, You.* Folate-PEG conjugates of a far-red light-activatable paclitaxel prodrug to improve selectivity towards folate receptor-positive cancer cells. ACS Omega 2017, 2, 6349-6360. [abstract]

  2. Li, M., Thapa, P., Rajaputra, P., Bio, M., Peer, C. J., Figg, W. D., You, Y.,* Woo, S.* Quantitative modeling of the dynamics and intracellular trafficking of far-red light-activatable prodrugs: implications in stimuli-responsive drug delivery system. J. Pharmacokinet. Pharmacodyn. 2017, 44, 521-536. [abstract] Journal Cover Article
       

  3. Bio, M., Rajaputra, P., Lim, I., Thapa, P., Tienabeso, B., Hurst, R. E., You, Y.* Efficient activation of visible light-activatable CA4 prodrug through intermolecular photo-unclick chemistry in mitochondria. Chem. Comm. 2017, 2017, 53, 1884-1887. [abstract]
    1. http://pubs.rsc.org/en/content/articlepdf/2017/cc/c6cc09994g

  4. Thapa, P., Li, M., Bio, M., Rajaputra, P., Nkepang, G., Sun, Y., Woo, S., You, Y.* Far-red light-activatable prodrug of paclitaxel for the combined effects of photodynamic therapy and site-specific paclitaxel chemotherapy. J. Med. Chem.   2016, 59, 3204–3214. [abstract] Highlighted in ChemistryViews
  5. http://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.5b01971

  6. Rajaputra, P., Bio, M., Nkepang, G., Thapa, P., Woo, S., You, Y.* Anticancer drug released from near IR-activated prodrug overcomes spatiotemporal limits of singlet oxygen. Bioorg. Med. Chem. 2016, 24, 1540-1549. [abstract]
  7. http://www.sciencedirect.com/science/article/pii/S0968089616301134

  8. Bio, M., Rajaputra, P., You, Y.* Photodynamic therapy via FRET following bioorthogonal click reaction in cancer cells. Bioorg. Med. Chem. Lett. 2016, 26, 145-148. [abstract]

  9. Muli, D. K., Rajaputra, P., You, Y.,* McGrath, D. V.* Asymmetric ZnPc–TEG photosensitizers: the effect of Pc substitution on phototoxicity. Tetrahedron Lett. 2015, 56, 6236-6239. [abstract]
     
  10. Hurst, R. E.,* Hauser, P. J., You, Y., Bailey-Downs, L. C., Bastian, A., Mathews, S. M., Thorpe, J., Earle, C., Bourguignon L. Y. Y., Ihnat, M. I. Identification of novel drugs to target dormant micrometastases, BMC Cancer 2015, 15, 404. [abstract].

  11. Watley, R. L., Awuah, S. G., Bio, M., Cantu, R., Gobeze, H. H., Nesterov, V., N., D'Souza, F.* You, Y.* Dual functioning thieno-pyrrole fused BODIPY dyes for NIR optical imaging and photodynamic therapy – singlet oxygen generation without heavy halogen atom assistance, Chem. Asian J. 2015, 10, 1335-1343. [abstract]
  12. http://onlinelibrary.wiley.com/doi/10.1002/asia.201500140/abstract   http://onlinelibrary.wiley.com/doi/10.1002/asia.201580604/abstract

  13. Nkepang, G., Bio, M., Rajaputra, P., Awuah, S., You, Y.* Folate receptor-mediated enhanced and specific delivery of far-red light-activatable prodrugs of Combretastatin A-4 to FR-positive tumor, Bioconjugate Chem. 2014, 25, 2175-2188. [abstract]

  14. Muli, D. K.,  Rajaputra, R., You, Y.*, McGrath, D. V.* Asymmetric ZnPc-Rhodamine B conjugates for mitochondrial targeted photodynamic therapy, Bioorg. Med. Chem. Lett. 2014, 24, 4496-4500 [abstract]
  15. http://www.sciencedirect.com/science/article/pii/S0960894X14008178


  16. Bandi, V., Das, S., Awuah, S., You, Y.*, D'Souza, F.*, Thieno-Pyrrole-Fused BODIPY – Fullerene Dyads: Utilization of Near-Infrared Sensitizers for Ultrafast Charge Separation in Donor-Acceptor Systems, J. Am. Chem. Soc. 2014, 136, 7571-7574. [abstract
    http://pubs.acs.org/doi/abs/10.1021/ja503015f

  17. Bio, M., Rajaputra, P., Nkepang, G., You, Y.*, A far-red light activatable, multi-functional prodrug for fluorescence optical imaging and combinational treatment, J. Med. Chem. 2014, 57, 3401-3409. [abstract]
           
  1. Nkepang, G., You, Y. Heteroatom-substituted dioxetanes and their emerging biomedical applications. In Patai's Chemistry of Functional Groups, Edited by I. Marek. John Wiley & Sons, Ltd: Chichester, UK.  Published online 04/28/2014. [abstract] - An Invited Book Chapter

  2. Awuah, S. G.; Das, S.; D'Souza, F.; You, Y.* Thieno-pyrrole fused BODIPY intermediate as platform for multi-functional NIR agents, Chemistry - An Asian Journal 2013, 8, 3123-3132. [abstract]

  3. Bio, M., You, Y.*, Emerging strategies for controlling drug release by using visible/near IR light, Med. Chem. 2013, 3, 192-198. [abstract] - An Invited Review Article
  4. https://www.omicsonline.org/emerging-strategies-for-controlling-drug-release-by-using-visiblenear-ir-light-2161-0444.1000138.php?aid=14325

  5. Bio, M., Rajaputra, P., Nkepang, G., Awuah, S. G., Hossion, A. M. L., You, Y.*, Site-specific and far-red light-activatable prodrug of combretastain A-4 using photo-unclick chemistry, J. Med. Chem. 2013, 56, 3936-3942. [abstract] - Highlighted in SciBX: Science-Business eXchange

  6. Ngen, E., Xiao, L., Rajaputra, P., Yan, X.*, You, Y.*, Enhanced singlet oxygen generation from porphyrin-rhodamine B dyad by two-photon excitation through resonance energy transfer, Photochem. Photobiol. 2013, 89, 841-848 [abstract]
  1. Rajaputra, P., Nkepang, G., Watley, R., You, Y.*, Synthesis and in vitro biological evaluation of lipophilic cation conjugated photosensitizers for targeting mitochondria, Bioorg. Med. Chem. 2013, 21 (2), 379-387.
 [abstract]
  1. Hossion, A. M. L., Bio, M., Nkepang, G., Awuah, S. G., You, Y.*, Visible light controlled release of anti-cancer drug through double activation of prodrug, ACS Med. Chem. Lett. 2013, 4, 124-127. [abstract] - Highlighted in the Editor's Choice
  1. Awuah, G. S., You, Y.*, Boron dipyrromethene (BODIPY) based photosensitizers for photodynamic therapy. RSC Advances 2012, 2(30), 11169-11183. [abstract] - Review Article - Top ten most accessed articles in September
  1. Bio, M., Nkepang, G., You, Y.*, Click and photo-unclick chemistry of aminoacrylate for visible light-triggered drug release, Chem. Comm. 2012, 48, 6517-6519. [abstract]
  1. Nkepang, G., Pogular, P.K., Bio, M., You, You.*, Synthesis and singlet oxygen reactivity of 1,2-diaryloxyethenes and selected sulfur and nitrogen analogs, Photochem. Photobiol. 2012, 88, 753-759. [abstract]
  1. Awuah, S. G., Polreis, J., Prakash, J., Qiao, Q., You, Y.*, New pyran dyes for dye-sensitized solar cells, J. Photochem. Photobiol. A 2011, 224, 116-122. [abstract]
  1. Paul, B., Rajaputra, P., You, Y.*, In vitro and in vivo photodynamic activity of core-modified porphyrin IY69 using 690 nm diode laser, Photochem. Photobiol. 2011, 87, 1468-1473. [abstract]
  1. Awuah, S. G., Polreis, J., Biradar, V., You, Y.*, Singlet oxygen generation by novel NIR BODIPY dyes, Org. Lett. 2011, 13, 3884-3887. [abstract]
  1. Johnson, C., Darling, S. B., You, Y.*, Density functional theory as a guide for the design of pyran dyes for dye sensitized solar cells, Monatsh. Chem. 2011, 142, 45-52.[abstract]
  1. Ngen, E. J., Rajaputra, P., You, Y.*, Evaluation of delocalized lipophilic cationic dyes as delivery vehicles for photosensitizers to mitochondria, Bioorg. Med. Chem. 2009, 17, 6631-6640.[abstract]
  1. Murthy, R. M., Bio, M., You, Y.*, Low energy light-triggered oxidative cleavage of olefins, Tetrahedron Lett. 2009, 50, 1041-1044[abstract]
  1. Xie, Y., Joshi, P., Ropp, M., Galipeau, D, Zhang, L., Fong, H., You, Y.*, Qiao, Q.*, Structural effects of core-modified porphyrins in dye-sensitized solar cells, J. Porphyrins Phthalocyanines 2009, 13, 903-909. [abstract]
  1. Minnes, M, Weitman, H., You, Y., Detty, M.R., Ehrenberg, B., Dithiaporphyrin derivatives as photosensitizers in membranes and cells. J. Phy. Chem. B 2008, 112, 3268-3276. [abstract]
  1. Ngen, E. J., Daniels, T. S., Murthy, R. S., Detty, M. R., You, Y.*, Core-modified porphyrins. Part 6: Effects of lipophilicity and core system on physicochemical and biological properties in vitro. Bioorg. Med. Chem. 2008, 16, 3171-3183[abstract]
  1. Chintharlapalli, S., Papineni, S., Liu, S., Jutooru, I., Chadalapaka, G., Cho, S., Murthy, R., You, Y., Safe, S., 2-Cyano-lup-1-en-3-oxo-20-oic acid, a cyano derivative of betulinic acid activates peroxisome proliferator-activated receptor g in colon and pancreatic cancer cells. Carcinogenesis 2007, 28, 2337-2346.  [abstract]
  1. You, Y.*, Daniels, T. S., Dominiak, P. M., Detty, M. R., Synthesis, spectral data, and crystal structure of two novel substitution patterns in dithiaporphyrins. J. Porphyrins Phthalocyanines 2007, 11, 1-8. [abstract]
  1. You, Y.*, Gibson, S. L., Detty, M. R., Phototoxicity of a core-modified porphyrin and induction of apoptosis. J. Photochem. Photobiol., B. 2006, 85, 155-162. [abstract]
  1. Tombline, G., Donnelly, D. J., Holt, J. J., You, Y., Ye, M., Gannon, M. K., Nygren, C. L., Detty, M. R., Stimulation of P-glycoprotein ATPase by analogues of tetramethylrosamine: coupling of drug binding at the "R" site to the ATP hydrolysis transition state. Biochemistry 2006, 45, 8037-8047. [abstract]
  1. Gibson, S. L., Holt, J. J., Ye, M., Donnelly, D. J., Ohulchanskyy, T. Y., You, Y., Detty, M. R., Structure-activity studies of uptake and phototoxicity with heavy-chalcogen analogues of tetramethylrosamine in vitro in chemosensitive and multidrug-resistant cells. Bioorg. Med. Chem. 2005, 13, 6394-6403. [abstract]
  1. You, Y.*, Gibson, S. L., Detty, M. R., Core-modified porphyrins. Part 5: electronic effects on photophysical and biological properties in vitro. Bioorg. Med. Chem. 2005, 13, 5968-5980. [abstract]
  1. You, Y.*, Gibson, S.L., Hilf, R., Ohulchanskyy, T.Y., Detty, M.R.,* Core-modified porphyrins. Part 4: steric effects on photophysical and biological properties in vitro. Bioorg. Med. Chem. 2005, 13, 2235-2261. [abstract]   
  1. You, Y.*, Podophyllotoxin Derivatives: Current synthetic approaches for new anticancer agents. Curr. Pharm. Design 200511, 1695-1717. (invited review) [abstract]
  1. Nam, N. H., Kim, Y., You, Y. J., Hong, D. H., Kim, H. M., Ahn, B. Z., New constituents from Crinum latifolium with inhibitory effects against tube-like formation of human umbilical venous endothelial cells. Nat. Prod. Res. 2004, 18, 485-491. [abstract]
  1. Nam, N. H., Hong, D. H., You, Y. J., Kim, Y., Bang, S. C., Kim, H. M., Ahn, B. Z., Synthesis and cytotoxicity of 2,5-dihydroxychalcones and related compounds. Arch. Pharm. Res. 2004, 27, 581-588. [abstract]
  1. You, Y., Kim, Y., Nam, N.H., Bang, S. C., Ahn, B.Z., Alkyl and carboxyalkyl esters of 4'-demethyl-4-deoxypodophyllotoxin: synthesis, cytotoxic, and antitumor activity. Europ. J. Med. Chem. 2004, 39, 189-193. [abstract]
  1. You, Y., Kim, Y., Nam, N.H., Ahn, B.Z., Lupane derivatives: synthesis and cytotoxic activity-III, A-ring modified derivatives. Bioorg. Med. Chem. Lett. 200313, 3137-3140. [abstract]
  1. You, Y., Gibson, S.L., Hilf, R., Davies, S.R., Oserff, A.R., Roy, I., Ohulchansky, T.Y., Bergey, E.J., Detty, M.R., Water-soluble, core-modified porphyrins. III. synthesis, photophysical properties, and in Vitro studies of cellular uptake, distribution and photosensitization with carboxilic acid substituted derivatives. J. Med. Chem. 2003, 46, 3734-3747. [abstract]
  1. You, Y., Kim, Y., Nam, N.H., Ahn, B.Z., Antitumor activity of unsaturated fatty acid esters of 4’-demethyldeoxypodophyllotoxin. Bioorg. Med. Chem. Lett. 2003, 13, 2629-2632. [abstract]
  1. Ahsan, K., Drake, M. D., Higgs, D. E., Wojciechowski, A. L., Tse, B. N., Beteman, M. A., You, Y., Detty, M. R., Dendrimeric organotelluride catalysts for the activation of hydrogen peroxide. Improved catalytic activity through statistical and stereoelectronic effects. Organometallics 2003, 22, 2883-2890. [abstract]
  1. You, Y., Kim, Y., Nam, N.H., Ahn, B.Z., Inhibitory effect of Adonis amurensis components on tube-like formation of human umbilical venous cells. Phytother. Res. 2003, 17, 568-570. [abstract]
  1. You, Y., Ahsan, K., Detty, M.R., Mechanistic studies of the tellurium(II)/tellurium(IV) redox cycle in thiol peroxidase-like reactions of diorganotellurides in methanol. J. Am. Chem. Soc. 2003, 125, 4918-4927. [abstract]
  1. You, Y., Nam, N.H., Kim, Y., Bae, K.H., Ahn, B.Z., Antiangiogenic activity of lupeol from Bombax ceiba. Phytother. Res. 2003, 17, 341-344. [abstract]
  1. Nam, N. H., Kim, Y., You, Y. J., Hong, D. H., Kim, H. M., Ahn, B. Z., Water soluble prodrugs of the antitumor agent 3-[(3-amino-4-methoxy)phenyl]-2-(3,4,5-trimethoxyphenyl)cyclopent-2-ene-1- one. Bioorg. Med. Chem. 2003, 11, 1021-1029. [abstract]
  1. Nam, N. H., Kim, Y., You, Y. J., Hong, D. H., Kim, H. M., Ahn, B. Z., Cytotoxic 2',5'-dihydroxychalcones with unexpected antiangiogenic activity. Eur. J. Med. Chem. 2003, 38, 179-187. [abstract]
  1. You, Y., Kim, Y., Nam, N.H., Ahn, B.Z., Synthesis and cytotoxic activity-II, aminoacetyl derivatives. Yakhak Hoeji 2002, 46, 301-306. [abstract]
  1. You, Y., Kim, Y., Ahn, B.Z., Lupane derivatives-I: synthesis and cytotoxic activity. Yakhak Hoeji 2002, 46, 295-300. [abstract]
  1. Cuong, N.-M., Nam, N.-H., Kim, Y., You, Y.-J., Bae, K.-H., Sung, T.-V., Ahn, B.-Z., Cytotoxic activity of Vietnamese herbal medicines against A549 cells. Kor. J. Pharmacogn. 2002, 33, 64-68. [abstract]
  1. Kim, Y., You, Y., Nam, N. H., Ahn, B. Z., Prodrugs of 4'-demethyl-4-deoxypodophyllotoxin: synthesis and evaluation of the antitumor activity. Bioorg. Med. Chem. Lett. 200212(23), 3435-3438. [abstract]
  1. Abe, M., You, Y., Detty, M. R., 21-Telluraporphyrins. II. Catalysts for bromination reactions with hydrogen peroxide and sodium bromide. Organometallics 2002, 21, 4546-4551. [abstract]
  1. You, Y., Lee, I.S., Kim, Y., Bae, K.H., Ahn, B.Z., Antiangiogenic activity of Bupleurum longiradiatum on human umbilical venous endothelial cells. Arch. Pharm. Res. 2002, 25(5), 640-642. [abstract]
  1. Nam, N. H., Kim, Y., You, Y. J., Hong, D. H., Kim, H. M., Ahn, B. Z., Synthesis, cytotoxicity and antitumor activity of 2,3-diarylcyclopent-2-ene-1-ones. Arch. Pharm. Res. 2002, 25, 600-607. [abstract]
  1. Nam, N. H., Kim, Y., You, Y. J., Hong, D. H., Kim, H. M., Ahn, B. Z., Synthesis and anti-tumor activity of novel combretastatins: combretocyclopentenones and related analogues. Bioorg. Med. Chem. Lett. 2002, 12, 1955-1958. [abstract]
  1. Nam, N. H., Kim, Y., You, Y. J., Hong, D. H., Kim, H. M., Ahn, B. Z., Preliminary structure-antiangiogenic activity relationships of 4-senecioyloxymethyl-6,7-dimethoxycoumarin. Bioorg. Med. Chem. Lett. 2002, 12, 2345-2348. [abstract]
  1. Nam, N. H., Kim, Y., You, Y. J., Hong, D. H., Kim, H. M., Ahn, B. Z., Synthesis and cytotoxicity of some rigid derivatives of methyl 2,5-dihydroxycinnamate. Arch. Pharm. Res. 2002, 25, 590-599. [abstract]
  1. Kim, Y., You, Y., Nam, N. H., Ahn, B. Z., 2,3-Dibenzylbutyrolactones and 1,2,3,4-tetrahydro-2-naphthoic acid gamma-lactones: structure and activity relationship in cytotoxic activity. Arch. Pharm. Res. 2002, 25, 240-249. [abstract]
  1. Kim, Y., You, Y., Kim, S. B., Ahn, B. Z., Deoxypodophyllotoxin; the cytotoxic and antiangiogenic component from Pulsatilla koreana Nakai. Planta Med. 2002, 68, 271-274. [abstract]
  1. Kim, Y., Nam, N. H., You, Y. J., Ahn, B. Z., Synthesis and cytotoxicity of 3,4-diaryl-2(5H)-furanones. Bioorg. Med. Chem. Lett. 2002, 12, 719-722. [abstract]
  1. Nam, N. H., Kim, Y., You, Y. J., Hong, D. H., Kim, H. M., Ahn, B. Z., Combretoxazolones: synthesis, cytotoxicity and antitumor activity. Bioorg. Med. Chem. Lett. 2001, 11, 3073-3076. [abstract]
  1. Kim, Y., You, Y. J., Ahn, B. Z., 6-(1-Acyloxyalkyl)-5,8-Dimethoxy-1,4-Naphthoquinones: Synthesis and evaluation of inhibitory effect on DNA topoisomerase-I and cytotoxic activity. Arch. Pharm. (Weinheim) 2001, 334, 318-322. [abstract]
  1. Jin, G. J., You, Y. J., Ahn, B .Z., Esters of 2-(1-hydroxy- alkyl)-1,4-dihydroxy-9,10-anthraquinones with melphalan as multifunctional anticancer agents. Bioorg. Med. Chem. Lett. 2001, 11, 1473-1476. [abstract]
  1. Shin, D. J., You, Y. J., Ahn, B. Z., 2-(1-Aminoacetylalkyl)-1,4-dihydroxy-9,10-antraquinones derivatives: synthesis and cytotoxic activity. Yakhak Hoeji 2001, 45, 133-139. [abstract]
  1. Nam, N. H., You, Y. J., Kim, Y., Hong, D. H., Kim, H. M., Ahn, B. Z., Synthesis of certain 3-aryl-2-propenoates and evaluation of their cytotoxicity. Bioorg. Med. Chem. Lett. 2001, 11, 1173-1176. [abstract]
  1. Jin, G.J., You, Y. J., Kim, Y., Nam, N. H., Ahn, B. Z., Esters of chlorambucil with 2-substituted 1,4-dihydroxy-9,10-anthraquinones as multifunctional anticancer agents. Europ. J. Med. Chem. 2001, 36, 361-366. [abstract]
  1. Song, G. Y., Kim, Y., You, Y. J., Cho, H., Ahn, B. Z., Naphthazarin derivatives (VII): antitumor action against ICR mice bearing ascitic S-180 cells. Arch. Pharm. Res. 2001, 24, 35-38. [abstract]
  1. You, Y., Kim, Y., Song, G. Y., Ahn, B. Z., (E)-6-(1-Alkyloxyiminoalkyl)-5,8-dimethoxy-1,4-naphthoquinones: synthesis, cytotoxic activity and antitumor activity. Bioorg. Med. Chem. Lett. 2000, 10, 2301-2303. [abstract]
  1. Bae, K. H., You, Y. J., Park, J. Y., An, R. B., Kim, Y. H., Kang, J. S., Ahn, B. Z., Screening of angiogenesis inhibitors from Korean plants (I). Kor. J. Pharmacogn. 2000, 31(3), 320-324. [abstract]
  1. Song, G. Y., Kim, Y., You, Y. J., Cho, H., Kim, S. H., Sok, D. E., Ahn, B. Z., Naphthazarin derivatives (VI): synthesis, inhibitory effect on DNA topoisomerase-I and antiproliferative activity of 2- or 6-(1-oxyiminoalkyl)-5,8-dimethoxy-1,4-naphthoquinones. Arch. Pharm. (Weinheim) 2000, 333, 87-92. [abstract] 
  1. Song, G. Y., Kim, Y., Zheng, X. G., You, Y. J., Cho, H., Chung, J. H., Sok, D. E., Ahn, B. Z., Naphthazarin derivatives (IV): synthesis, inhibition of DNA topoisomerase I and cytotoxicity of 2- or 6-acyl-5,8-dimethoxy-1, 4-naphthoquinones. Eur. J. Med. Chem. 2000, 35, 291-298. [abstract]
  1. Do, Q. V., Pharm, G. D., Mai, N. T., Nguyen, H. N., You, Y. J., Ahn, B. Z., Cytotoxicity of some anthraquinones from the stem of Morinda citrifolia growing in Vietnam. Tap chi Hoa hoc (Vietnamese J. of Chemistry) 1999, 37, 94-97.
  1. Song, G. Y., Zheng, X. G., Kim, Y., You, Y. J., Sok, D. E., Ahn, B. Z., Naphthazarin derivatives (II): formation of glutathione conjugate, inhibition of DNA topoisomerase-I and cytotoxicity. Bioorg. Med. Chem. Lett. 1999, 9, 2407-2412. [abstract]
  1. Zheng, X. G., Kang, J. S., Kim, Y., You, Y. J., Jin, G. Z., Ahn, B. Z., Glutathione conjugates of 2- or 6-substituted 5,8-dimethoxy-1,4-naphthoquinone derivatives: formation and structure. Arch. Pharm. Res. 1999, 22, 384-390. [abstract]
  1. You, Y. J., Ahn, B. Z., 6-(1-Alkenoyloxyalkyl)-5,8-dimethoxynaphthoquinone derivatives: synthesis and evaluation of antitumor activity. Arch. Pharm. Res. 1998, 21(6), 738-743. [abstract]
  1. You, Y. J., Zheng, X. G., Kim, Y., Ahn, B. Z., Naphthazarin derivatives: synthesis, formation of glutahtione conjugate, inhibition of DNA topoisomerase-I and antitumor activity. Arch. Pharm. Res. 1998, 21, 595-598. [abstract]